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Wheat, grains, and the battle for B12

By Dr. Davis | August 19, 2019

Vitamin B12 containing foods

 

Nutrient deficiencies from wheat/grain consumption are common, especially deficiencies of positively-charged minerals magnesium, calcium, iron, and zinc, due to grain phytates that block their absorption. But deficiency of vitamin B12 can also occur for other reasons unrelated to grain phytates but due to other effects of wheat and grains that, if not corrected, can lead to vitamin B12 deficiency and serious adverse health effects.

Gastrointestinal absorption of vitamin B12 can be tenuous because it requires the participation of two factors/sites: so-called intrinsic factor produced by the parietal cells of the stomach to bind B12 from food or supplements and a healthy distal ileum (just before the colon) for absorption. Parietal cells are also the source for production of stomach acid (HCl) necessary for extracting vitamin B12 from food; damaged or lost parietal cells therefore also fail to produce sufficient stomach acid, a common situation called hypochlorhydria, reduced stomach acid. Disruption at either site will therefore impair vitamin B12 absorption and lead, over time, to deficiency. Wheat and grains can disrupt health at both sites.

Wheat germ agglutinin from wheat, rye, barley, and rice can block intrinsic factor, while gliadin from wheat and proteins from related grains (secalin in rye, hordein in barley) provokes formation of antibodies against both intrinsic factor and stomach parietal cells, leading to autoimmune destruction and atrophy of the stomach lining, autoimmune gastritis. People with Crohn’s disease are especially vulnerable to vitamin B12 deficiency, since the distal ileum is inflamed in this condition and may require months to years to recover the ability to absorb B12.

To make matters worse, it is becoming clear that many species of bowel flora produce B vitamins, including vitamin B12. Disrupted bowel flora, or dysbiosis, can be responsible for adding to a lack of B12. People who are overweight or obese or have type 2 diabetes, for instance, have increased populations of Firmicutes that do not produce B vitamins, thereby competing with species that produce B12. Should small intestinal bacterial overgrowth, SIBO, develop due to the lack of stomach acid, then the B12 situation is worsened further due to proliferation of non-B-producing pathogenic bacterial species.

Vitamin B12 deficiency is suggested by symptoms such as impaired mental performance/clarity, deteriorating nervous system function, low energy, an enlarged liver, a cherry red tongue, and a specific form of anemia called macrocytic anemia due to abnormally enlarged red blood cells (signaled by a high mean corpuscular volume, or MCV, value on a CBC). You may recall that removing grains, restoring vitamin D, and cultivation of healthy bowel flora can reverse autoimmune inflammation. Unfortunately, some organs, such as the thyroid or the beta cells of the pancreas, are poor at recovering once autoimmune damage has been inflicted, and there is little hope of recovering organ function. The same can be true for autoimmune damage to the stomach’s parietal cells that produce intrinsic factor: remove the original cause of damage (gliadin and related proteins), but parietal cells may not recover. This means long-term dependence on vitamin B12 supplementation.

Vitamin B12 deficiency is identified by measurement of cobalamin or holocobalamin on a blood test, as well as an increased level of methylmalonic acid that can detect milder degrees of deficiency. When restoring vitamin B12, aim to achieve cobalamin and holocobalamin levels in the upper half of the reference range, as levels in the lower half of cobalamin and holocobalamin levels can still be associated with persistent problems including neuropathy, impaired balance, and memory. For the majority, oral (or sublingual, i.e., beneath the tongue, if poor absorption is suspected) supplementation with higher doses in the 500 to 1000 mcg per day range get the job done; rarely are injectable forms required. Because vitamin B12 is most plentiful in animal products such as meat, liver, and eggs, vegans and vegetarians should consider lifelong B12 supplementation. The best form of B12 is methylcobalamin, rather than the more common cyanocobalamin, as the methyl- form is better absorbed and sidesteps the question of potential cyanide toxicity with the cyano-form.

An even better solution? Avoid the thing that got this ball rolling in the first place: eat no wheat nor grains and thereby don’t experience intrinsic factor disruption by wheat germ agglutinin, don’t develop autoimmune gastritis that impairs intrinsic factor and stomach acid production, maintain normal stomach acid to protect yourself against dysbiosis/SIBO. And do this early as possible in life before the entire constellation of effects become established.

You can also appreciate how deep the fictions surrounding “healthy whole grains” can be. We are told over and over again that whole grains are filled with fiber and B vitamins, but not told that numerous deficiencies can develop, including B12 deficiency, regardless of how much is added to grains to compensate. Notice that grains are the only foods that are “fortified” with B vitamins?

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Filed Under: Wheat-Free Lifestyle Tagged With: undoctored, vitamin b12, wheat belly

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About Dr. Davis

Cardiologist Dr. William Davis is a New York
Times #1 Best Selling author and the Medical Director of the Wheat Belly Lifestyle Institute and the Undoctored Inner Circle program.

Nothing here should be construed as medical advice, but only topics for further discussion with your doctor. I practice cardiology in Milwaukee, Wisconsin.

Comments & Feedback...

  1. Brian Kerr

    August 19, 2019 at 11:53 am

    grain phytates … are there any other foods which have harmful
    phytates that we should not eat ?

    • Bob Niland

      August 19, 2019 at 6:31 pm

      Brian Kerr wrote: «grain phytates … are there any other foods which have harmful
      phytates that we should not eat ?
      »

      Apparently not (as long as we restrict the list to foods otherwise compatible with the program).

      The canary in the mine might be magnesium. If phytates in other foods (such as nuts) were an issue, it might be expected to show up in Mg levels, and doesn’t. Although testing an RBC-Mg level is encouraged, most people on WB/Undoctored merely supplement to 400-500 mg of Mg per day, and leave it at that.

      Nonetheless, many people do test Mg at least once, if not track it. If, for example, the almond flour in the recipes was causing mineral issues, we’d know about it.
      ________
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